Butylboronic Acid → HCID 68863966, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of Example 112A (115 mg, 0.25 mmol), K3PO4 (185 mg, 0.875 mmol), n-butylboronic acid (34 mg, 0.325 mmol), and bis(tricyclohexylphosphine)palladium dichloride (18 mg, 0.025 mmol) in toluene (4 mL) and water (0.2 mL) was purged with nitrogen and stirred at 100° C. for 24 hours. The mixture was then directly chromatographed on a silica gel column, eluting with 30% ethyl acetate/hexanes to provide the desired product (87 mg, 39.7%).

Provenance & Evidence