HCID 68864277, compound → HCID 23647766, compound

HRID 1725934Notes

Reaction equation

HRID 1725934 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[C:17]([C:18]([O:20]CC3C=CC=CC=3)=[O:19])=[C:16]([CH3:28])[C:15]([CH2:29][OH:30])=[CH:14][CH:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1>CO.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][C:12]2[C:17]([C:18]([OH:20])=[O:19])=[C:16]([CH3:28])[C:15]([CH2:29][OH:30])=[CH:14][CH:13]=2)(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 68864277HCID 68864277, compound

Product 1

HCID 23647766HCID 23647766, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of Example 234A (71 mg, 0.17 mmol) in methanol (8 mL) was treated with 10% Pd/C (0.15 g) for 1 hour under a hydrogen atmosphere. Filtration and solvent evaporation gave the desired compound. 1H NMR (DMSO-d6) δ 2.15 (s, 3H), 4.43 (s, 2H), 5.15 (br s, 1H), 6.77 (d, 1H), 7.28 (d, 1H), 7.30-7.41 (m, 2H), 7.75-7.79 (m, 2H), 9.62 (s, 1H), 13.05 (br s, 1H); MS (ESI(−)) m/e 338 (M−H)−.

Workup

  1. filtrationFiltration and solvent evaporation

Sources & evidence

ORD record
ord-8e7011636ac346dbbc16c8b9b7bebe3a
Source dataset
uspto-grants-2009_02
Patent number
US07491718B2

Reaction notes

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