Hydrochloric Acid → HCID 11494819, compound

Participants

Reaction Conditions

Reaction Steps

A solution of Example 379A (3.04 g, 7.54 mmol) in methanol (70 mL) and distilled water (7.8 mL) was treated with lithium hydroxide monohydrate (1.58 g, 37.7 mmol), heated to 60° C. overnight, cooled to room temperature, treated with 1N HCl, and concentrated. The aqueous layer was washed with dichloromethane two times and the combined organic phases were dried (MgSO4), filtered, and concentrated to provide the desired product. MS (ESI(+)) m/e 388 (M+H)+; 1H NMR (300 MHz, DMSO-d6) δ 14.00 (br s, 1H), 8.85 (br s, 1H), 7.83 (d, 1H), 7.73 (m, 2H), 7.64 (m, 1H), 7.13 (s, 2H), 3.63 (s, 3H), 2.67 (br s, 2H), 2.51 (br s, 2H), 1.65 (br m, 4H).

Provenance & Evidence