HCID 11518441, compound → HCID 11496527, compound

Participants

Reaction Steps

A mixture of Example 529D (300 mg, 0.64 mmol) in methanol (12 mL) was hydrogenated with H2 over 90 mg (30 wt %) of 10% Pd/C. After 4.5 hours the reaction was filtered through diatomaceous earth (Celite®). The pad was washed with methanol and the filtrates were combined with those from a 50 mg scale (0.11 mmol) reaction and concentrated to provide 332 mg (94%) of the desired product. MS (ESI(+)) m/e 473 (M+H)+; 1H NMR (400 MHz, CDCl3) δ 1.00 (t, J=7.14 Hz, 6H) 1.58 (m, 2H) 1.68 (m, 6H) 2.53 (m, 6H) 2.69 (m, 4H) 2.95 (m, 2H) 3.72 (s, 3H) 6.99 (d, J=8.51 Hz, 1H) 7.05 (d, J=8.37 Hz, 1H) 7.21 (t, J=7.68 Hz, 1H) 7.30 (d, J=7.55 Hz, 1H) 7.42 (t, J=7.14 Hz, 1H) 7.85 (d, J=7.82 Hz, 1H).

Provenance & Evidence