HCID 68862448, compound → HCID 68863786, compound

Participants

Reaction Steps

A 1:1.2 mixture of Example 595C and Example 596A (408 mg, 0.84 mmol) was hydrogenated over 120 mg of 10% Pd/C in 16 mL of methanol for 1 hour. The reaction mixture was filtered through diatomaceous earth (Celite®), and concentrated to provide 332 mg (81%) of the title compound. 1H NMR (400 MHz, CDCl3) δ 1.16 (t, J=7.14 Hz, 6H) 1.42 (m, 2H) 1.67 (m, 8H) 2.62 (m, 2H) 2.72 (m, 8H) 2.88 (m, 2H) 3.75 (s, 3H) 7.03 (d, J=8.51 Hz, 1H) 7.18 (d, J=8.37 Hz, 1H) 7.22 (m, 1H) 7.29 (dd, J=7.75, 1.17 Hz, 1H) 7.44 (td, J=7.48, 1.37 Hz, 1H) 7.84 (dd, J=7.96, 1.37 Hz, 1H).

Provenance & Evidence