4-Fluorophenol → HCID 68859859, compound

Participants

Reaction Steps

α-Bromobutyrolactone (12.4 g, 0.075 mol) is added to a mixture of 4-fluorophenol (5.6 g, 0.05 mol) and caesium carbonate (17.9 g, 0.055 mol) in acetone (100 ml). The reaction medium is refluxed for two hours. After cooling to room temperature, the reaction is filtered through a bed of Celite and the filtrate is evaporated. The oily residue is purified by flash chromatography (1/2 EtOAc/heptane) to give the expected product in the form of an oil (9.8 g, 87%).

Provenance & Evidence