Hydrochloric Acid → HCID 178527072, compound

Participants

Reaction Steps

A solution of 200 mg of 3-(1-tert-butoxycarbonyl-2,3-dihydro-1H-indol-2-yl)-5-(diphenylphosphinoyloxy)indazole-1-carboxylic acid tert-butyl ester in 4 ml of dioxane and 1 ml of a 4M hydrochloric acid solution in dioxane is stirred at ambient temperature. After 1 hour, 1 ml of a 4M hydrochloric acid solution in dioxane is added. The reaction medium is stirred overnight at ambient temperature. The suspension is filtered through sintered glass. The solid is rinsed with ethyl ether. The solid is taken up in 200 ml of dichloromethane and 8 ml of a 2N aqueous sodium hydroxide solution. The solution is stirred for a few minutes and is then separated by settling out. The organic phase is dried over magnesium sulfate, filtered, and concentrated under reduced pressure to obtain 114 mg of diphenylphosphinic acid 3-(2,3-dihydro-1H-indol-2-yl)-1H-indazol-5-yl ester.

Provenance & Evidence