Ammonium formate → HCID 57562455, compound

Participants

Reaction Steps

A solution of 740 mg of 5-benzyloxy-3-[1-tert-butoxycarbonyl-5-(2-morpholin-4-ylethoxy)-1H-indol-2-yl]indazole-1-carboxylic acid tert-butyl ester, of 328 mg of ammonium formate and of 234 mg of 10% palladium-on-charcoal in 56 ml of ethanol is heated at 70° C. for 35 minutes. The reaction mixture is then cooled to ambient temperature. The catalyst is filtered through paper and washed abundantly with ethanol to obtain 533 mg of the crude compound 3-[1-tert-butoxycarbonyl-5-(2-morpholin-4-ylethoxy)-1H-indol-2-yl]-5-hydroxyindazole-1-carboxylic acid tert-butyl ester.

Provenance & Evidence