3-[1-tert-butoxycarbonyl-5-(2-morpholin-4-ylethoxy)-1H-indol-2-yl]-5-(methylphenylphosphinoyloxy)indazole-1-carboxylic acid tert-butyl ester → methylphenylphosphinic acid 3-[5-(2-morpholin-4-ylethoxy)-1H-indol-2-yl]-1H-indazol-5-yl ester

Participants

Reaction Steps

A solution of 10.5 mg of 3-[1-tert-butoxycarbonyl-5-(2-morpholin-4-ylethoxy)-1H-indol-2-yl]-5-(methylphenylphosphinoyloxy)indazole-1-carboxylic acid tert-butyl ester in a mixture of 500 μl of dichloromethane and 500 μl of trifluoroacetic acid is agitated at ambient temperature for 4 hours. The reaction medium is evaporated under a stream of nitrogen and then redissolved in 1.4 ml of DMSO. The solution obtained is stirred at 60° C. for 3 days and then purified by LC/MS to obtain 5.1 mg of methylphenylphosphinic acid 3-[5-(2-morpholin-4-ylethoxy)-1H-indol-2-yl]-1H-indazol-5-yl ester.

Provenance & Evidence