Triethylamine → HCID 178476928, compound

Participants

Reaction Steps

Procedure H is followed, introducing 70 mg (1 eq; 0.190 mmol) of trifluoromethanesulfonic acid 3-((E)-styryl)-1H-indazol-5-yl ester in solution in 3 ml of dimethylformamide, 26.7 μl (1.09 eq; 0.207 mmol) of diethylphosphite, 8.9 mg (0.04 eq-0.0076 mmol) of tetrakis(triphenylphosphine)palladium(0) and 28.8 μl (1.09 eq; 0.207 mmol) of triethylamine. The additions made are successively 27 μl of diethylphosphite, 29 μl of triethylamine, 10 mg of tetrakis(triphenylphosphine)palladium(0), then 50 μl of diethylphosphite, 50 μl of triethylamine, 20 mg of tetrakis(triphenylphosphine)palladium(0) and, finally, 27 μl of diethylphosphite, 29 μl of triethylamine and 9 mg of tetrakis(triphenylphosphine) palladium(0). 22 mg of [3-((E)-styryl)-1H-indazol-5-yl]phosphonic acid diethyl ester are isolated, along with 8.7 mg of [3-((E)-styryl)-1H-indazol-5-yl]phosphonic acid monoethyl ester.

Provenance & Evidence