Sodium Bicarbonate → HCID 86598873, compound

Participants

Reaction Conditions

Reaction Steps

44.8 mg (0.25 eq; 0.039 mmol) of tetrakis(triphenylphosphine)palladium(0), 39.6 mg (2 eq; 0.310 mmol) of 2-thiopheneboronic acid, 3 ml of dimethylformamide and 150 μl of saturated sodium bicarbonate solution are added to 70 mg (1 eq; 0.155 mol) of 5-(dimethoxyphosphoryl)-3-iodoindazole-1-carboxylic acid tert-butyl ester. The medium is stirred at 130° C. for 5 hours. The reaction medium is filtered through paper and the solvent is evaporated off under reduced pressure in a rotary evaporator. The reaction crude is purified by LC/MS to obtain 2 mg of (3-thiophen-2-yl-1H-indazol-5-yl)phosphonic acid dimethyl ester (40% purity by NMR), along with 12.9 mg of (3-thiophen-2-yl-1H-indazol-5-yl)phosphonic acid monomethyl ester.

Provenance & Evidence