Potassium Iodide → HCID 68840237, compound

Participants

Reaction Steps

The compound 5-benzyloxy-3-[1-tert-butoxycarbonyl-6-(2-diethylaminoethoxy)-1H-indol-2-yl]indazole-1-carboxylic acid tert-butyl ester is prepared according to procedure N using 1.23 g of 5-benzyloxy-3-[6-(2-bromoethoxy)-1-tert-butoxycarbonyl-1H-indol-2-yl]indazole-1-carboxylic acid tert-butyl ester, 50 ml of acetonitrile, 401 mg of potassium iodide, 204 mg of diethylamine, and 770 mg of cesium carbonate. After treatment, the reaction crude is purified by chromatography on a cartridge of 20 g of silica; eluent: 98/2, 95/5, 92/8 dichloromethane/methanol to obtain 390 mg of 5-benzyloxy-3-[1-tert-butoxycarbonyl-6-(2-diethylaminoethoxy)-1H-indol-2-yl]indazole-1-carboxylic acid tert-butyl ester.

Provenance & Evidence