Methyl iodide → 1-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide

Participants

Reaction Steps

To a solution of 1-ethyl-4-piperidone (21.0 g, 0.165 mol) in acetone (175 mL) cooled to 10° C. was added a solution of MeI (12.3 mL, 0.198 mmol) in acetone (15 mL) dropwise. The mixture was stirred at room temperature overnight and the precipitate was isolated by filtration, washed with acetone and dried in vacuo to give 1-ethyl-1-methyl-4-oxo-piperidinium iodide as a pale yellow solid (42.03 g, 95%).

Provenance & Evidence