HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)aniline → 1-Boc-4-(4-Trifluoromethyl-phenylamino)-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Reactant | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Product | 1-Boc-4-(4-Trifluoromethyl-phenylamino)-piperidine | HCID 22029142 | 40% |
Reaction Steps
Using general procedure A, 4-trifluoromethylaniline (2.02 g, 12.5 mmol) and 1-Boc-4-piperidone (2.5 g, 12.5 mmol) afforded 4-(4-trifluoromethyl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester (1.71 g, 40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491735B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-eaa147aa786e4a1e8dfa86cdf7a5d0e5 |
| Source note | uspto-grants-2009_02 |