HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 4-[Benzyl-(4-methoxyphenyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | tert-butyl 4-(4-methoxyanilino)tetrahydro-1(2H)-pyridinecarboxylate | HCID 2776119 | — |
| Product | 4-[Benzyl-(4-methoxyphenyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester | HCID 68970013 | 87% |
Reaction Steps
Using general procedure H, 4-(4-methoxyphenylamino)-piperidine-1-carboxylic acid tert-butyl ester (see EXAMPLE 77) (612 mg, 2.00 mmol) and benzyl bromide (410 mg, 2.40 mmol) gave 4-[benzyl-(4-methoxyphenyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester as a colorless oil (688 mg, 87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491735B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-af423854dc9240ffb76f22a9bf7f8ad4 |
| Source note | uspto-grants-2009_02 |