2-(3-Oxobutyl)isoindoline-1,3-dione → [1-(3-Amino-1-methylpropyl)-piperidin-4-yl]-benzyl-(4-methoxy-phenyl)-amine

Participants

Role	Name	HCID	Charge
Reactant	2-(3-Oxobutyl)isoindoline-1,3-dione	HCID 290728	—
Reactant	4-[Benzyl-(4-methoxyphenyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester	HCID 68970013	—
Product	[1-(3-Amino-1-methylpropyl)-piperidin-4-yl]-benzyl-(4-methoxy-phenyl)-amine	HCID 68972467	—

Reaction Steps

Using general procedure C with the above carbamate (303 mg, 0.765 mmol), then general procedure B with the resulting amine and 2-(3-oxo-butyl)-isoindole-1,3-dione (320 mg, 1.47 mmol) and then using general procedure D gave [1-(3-amino-1-methylpropyl)-piperidin-4-yl]-benzyl-(4-methoxy-phenyl)-amine as a colorless oil (190 mg, 68% over 3 steps).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07491735B2
Source dataset	uspto-grants-2009_02
ORD ID	ord-cece953307a74e6c9c1d07de1646d741
Source note	uspto-grants-2009_02