Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitrogen | HCID 947 | — |
| Reactant | 1-Iodo-4-nitrobenzene | HCID 12495 | — |
| Reactant | tert-Butyl 4-(benzylamino)piperidine-1-carboxylate | HCID 15380687 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 68970609 | HCID 68970609 | 37% |
Reaction Steps
A solution of the above amine (500 mg, 1.72 mmol), 1-iodo-4-nitrobenzene (408 mg, 1.64 mmol), Pd2(dba)3, (±)BINAP and toluene was purged with N2 and then heated to 100° C. for 24 h to afford 4-[benzyl-(4-nitro-phenyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester as a yellow foam (250 mg, 37%) following aqueous work-up and purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07491735B2 |
|---|
| Source dataset | uspto-grants-2009_02 |
|---|
| ORD ID | ord-745c47f72ee345b6b9b4c8d934929e41 |
|---|
| Source note | uspto-grants-2009_02 |
|---|
