Benzenemethanamine, 3-chloro- → HCID 53255647, compound

HRID 1726156Notes

Reaction equation

HRID 1726156 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][NH2:6].[C:10]([N:17]1[CH2:22][CH2:21][C:20](=O)[CH2:19][CH2:18]1)([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11]>>[C:13]([O:12][C:10]([N:17]1[CH2:22][CH2:21][CH:20]([NH:6][CH2:5][C:4]2[CH:7]=[CH:8][CH:9]=[C:2]([Cl:1])[CH:3]=2)[CH2:19][CH2:18]1)=[O:11])([CH3:16])([CH3:14])[CH3:15]

Participants

3

Reactant 2

HCID 77802Benzenemethanamine, 3-chloro-HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 53255647HCID 53255647, compoundYield 89.6%

Procedure

Using general procedure A, 3-chlorobenzylamine (0.27 mL, 2.2 mmol) and 1-Boc-4-piperidone (484 mg, 2.4 mmol) afforded 4-(3-chloro-benzylamino)-piperidine-1-carboxylic acid tert-butyl ester as a colourless oil (640 mg, 89%).

Sources & evidence

ORD record
ord-5e63069443d74556968e91326ddf3525
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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