tert-Butyl 4-oxopiperidine-1-carboxylate → HCID 68973756, compound

HRID 1726157Notes

Reaction equation

HRID 1726157 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[NH2:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([N:25]([CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)(=[O:24])=[O:23])=[CH:18][CH:17]=1>>[C:4]([O:3][C:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:15][C:16]2[CH:17]=[CH:18][C:19]([S:22](=[O:24])(=[O:23])[N:25]([CH2:26][C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH2:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)=[CH:20][CH:21]=2)[CH2:10][CH2:9]1)=[O:2])([CH3:7])([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 15420472HCID 15420472, compound

Product 1

HCID 68973756HCID 68973756, compoundYield 55%

Procedure

Using general procedure A, 1-Boc-4-piperidone (1.00 g, 5.03 mmol) and 4-amino-N,N-dibenzyl-benzenesulfonamide (Mikhura, I. V.; et al., Russ. J. Org. Chem., 36, 1, 2002, 64-68) (1.53 g, 4.34 mmol) afforded 4-(4-dibenzylsulfamoyl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester as a white solid (1.27 g, 55%).

Sources & evidence

ORD record
ord-e0434c258df941ebafa4637868489881
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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