3,5-Dichloroisonicotinic acid → HCID 11376779, compound

HRID 1726159Notes

Reaction equation

HRID 1726159 reaction equation
ClC1C=NC=C(Cl)C=1C(O)=O.[CH2:12]([N:19]([C:41]1[CH:46]=[CH:45][C:44]([S:47](=[O:60])(=[O:59])[NH:48]C(C2C(Cl)=CN=CC=2Cl)=O)=[CH:43][CH:42]=1)[CH:20]1[CH2:25][CH2:24][N:23]([CH:26]([CH3:40])[CH2:27][CH2:28][NH:29][C:30](=[O:39])[C:31]2[C:36]([Cl:37])=[CH:35][N:34]=[CH:33][C:32]=2[Cl:38])[CH2:22][CH2:21]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([N:19]([C:41]1[CH:42]=[CH:43][C:44]([S:47](=[O:60])(=[O:59])[NH2:48])=[CH:45][CH:46]=1)[CH:20]1[CH2:21][CH2:22][N:23]([CH:26]([CH3:40])[CH2:27][CH2:28][NH:29][C:30](=[O:39])[C:31]2[C:36]([Cl:37])=[CH:35][N:34]=[CH:33][C:32]=2[Cl:38])[CH2:24][CH2:25]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 6057633,5-Dichloroisonicotinic acidHCID 68974258HCID 68974258, compound

Product 1

HCID 11376779HCID 11376779, compound

Procedure

Using general procedure F, 3,5-dichloroisonicotinic acid (87 mg, 0.45 mmol) and the above amine (58 mg, 0.14 mmol) afforded the desired product and N-{3-[4-(benzyl-{4-[(3,5-dichloro-pyridine-4-carbonyl)-sulfamoyl]-phenyl}-amino)-piperidin-1-yl]-butyl}-3,5-dichloro-isonicotinamide.

Sources & evidence

ORD record
ord-c20ebf0d6c3d4e599920a3a5b0084234
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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