HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorobenzylamine → tert-Butyl 4-{[(3-fluorophenyl)methyl]amino}piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorobenzylamine | HCID 66853 | — |
| Reactant | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Product | tert-Butyl 4-{[(3-fluorophenyl)methyl]amino}piperidine-1-carboxylate | HCID 42880208 | 91.4% |
Reaction Steps
Using general procedure A, 3-fluorobenzylamine (0.25 mL, 2.2 mmol) and 1-Boc-4-piperidone (482 mg, 2.4 mmol) afforded 4-(3-fluoro-benzylamino)-piperidine-1-carboxylic acid tert-butyl ester as a colourless oil (620 mg, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491735B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-edef54713d854e59a39593083e51c8ac |
| Source note | uspto-grants-2009_02 |