Methyl 4-aminobenzoate → HCID 56777230, compound

HRID 1726161Notes

Reaction equation

HRID 1726161 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.[C:12]([N:19]1[CH2:24][CH2:23][C:22](=O)[CH2:21][CH2:20]1)([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]>>[C:15]([O:14][C:12]([N:19]1[CH2:24][CH2:23][CH:22]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:10][CH:11]=2)[CH2:21][CH2:20]1)=[O:13])([CH3:18])([CH3:16])[CH3:17]

Participants

3

Reactant 2

HCID 12082Methyl 4-aminobenzoateHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 56777230HCID 56777230, compoundYield 77%

Procedure

Using general procedure A, methyl 4-aminobenzoate (380 mg, 2.51 mmol) and 1-Boc-4-piperidone (500 g, 2.51 mmol) afforded 4-(4-methoxycarbonyl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester (643 mg, 77%).

Sources & evidence

ORD record
ord-4638ac2ec2c144288a1c07f62ad53ea0
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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