Methanol → HCID 596153, compound

HRID 1726169Notes

Reaction equation

HRID 1726169 reaction equation
[N+:1]([C:4]1[CH:20]=[CH:19][C:7]([C:8]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=2)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].S(=O)(=O)(O)O.[CH3:26]O>>[CH3:26][O:15][C:14](=[O:16])[C:13]1[CH:17]=[CH:18][C:10]([C:8](=[O:9])[C:7]2[CH:19]=[CH:20][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)=[CH:11][CH:12]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 3084824-(4-Nitro-benzoyl)-benzoic acid

Product 1

HCID 596153HCID 596153, compoundYield 94%

Procedure

A solution of 4-(4-nitro-benzoyl)-benzoic acid (Dinsmore, Christopher J.; et al., Bioorg. Med. Chem. Lett., 7, 10, 1997, 1345-1348) (4.00 g, 14.7 mmol) and sulfuric acid (1.2 mL) in MeOH (40 mL) was heated at reflux for 18 h. The mixture was filtered and after work-up gave 4-(4-nitro-benzoyl)-benzoic acid methyl ester as a yellow solid (3.97 g, 94%).

Workup

  1. temperatureat reflux for 18 h
  2. filtrationThe mixture was filtered

Sources & evidence

ORD record
ord-99205fa419a44ebd84e6e543e9fde78f
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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