tert-Butyl 4-oxopiperidine-1-carboxylate → HCID 68970456, compound

HRID 1726170Notes

Reaction equation

HRID 1726170 reaction equation
[CH3:1][O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)=[CH:6][CH:5]=1.[C:19]([N:26]1[CH2:31][CH2:30][C:29](=O)[CH2:28][CH2:27]1)([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20]>>[C:22]([O:21][C:19]([N:26]1[CH2:31][CH2:30][CH:29]([NH:17][C:14]2[CH:15]=[CH:16][C:11]([CH2:10][C:7]3[CH:6]=[CH:5][C:4]([C:3]([O:2][CH3:1])=[O:18])=[CH:9][CH:8]=3)=[CH:12][CH:13]=2)[CH2:28][CH2:27]1)=[O:20])([CH3:25])([CH3:23])[CH3:24]

Participants

3

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 68972848HCID 68972848, compound

Product 1

HCID 68970456HCID 68970456, compoundYield 37.9%

Procedure

Using general procedure A, 4-(4-amino-benzyl)-benzoic acid methyl ester (0.66 g, 2.7 mmol) and 1-Boc-4-piperidone (545 mg, 2.74 mmol) gave 4-[4-(4-methoxycarbonyl-benzyl)-phenylamino]-piperidine-1-carboxylic acid tert-butyl ester as a yellow foam (434 mg, 36%).

Sources & evidence

ORD record
ord-2fc4d033494a47d9b67c29331cba6bbd
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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