tert-Butyl 4-oxopiperidine-1-carboxylate → HCID 68970763, compound

HRID 1726171Notes

Reaction equation

HRID 1726171 reaction equation
[CH3:1][O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)[OH:11])=[CH:6][CH:5]=1.[C:20]([N:27]1[CH2:32][CH2:31][C:30](=O)[CH2:29][CH2:28]1)([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21]>>[C:23]([O:22][C:20]([N:27]1[CH2:32][CH2:31][CH:30]([NH:18][C:15]2[CH:16]=[CH:17][C:12]([CH:10]([OH:11])[C:7]3[CH:6]=[CH:5][C:4]([C:3]([O:2][CH3:1])=[O:19])=[CH:9][CH:8]=3)=[CH:13][CH:14]=2)[CH2:29][CH2:28]1)=[O:21])([CH3:26])([CH3:24])[CH3:25]

Participants

3

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 68974337HCID 68974337, compound

Product 1

HCID 68970763HCID 68970763, compoundYield 85.1%

Procedure

Using general procedure A, 4-[(4-amino-phenyl)-hydroxy-methyl]-benzoic acid methyl ester (see EXAMPLE 100) (1.40 g, 5.44 mmol) and 1-Boc-4-piperidone (1.63 g, 8.18 mmol) gave 4-{4-[hydroxy-(4-methoxycarbonyl-phenyl)-methyl]-phenylamino}-piperidine-1-carboxylic acid tert-butyl ester as a pale solid (2.04 g, 85%).

Sources & evidence

ORD record
ord-0a5adce46aa948678965f602529f902f
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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