4-Amino-N,N-dimethylbenzamide → HCID 68968986, compound

HRID 1726175Notes

Reaction equation

HRID 1726175 reaction equation
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([N:8]([CH3:10])[CH3:9])=[O:7])=[CH:4][CH:3]=1.[C:13]([N:20]1[CH2:25][CH2:24][C:23](=O)[CH2:22][CH2:21]1)([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14]>>[C:16]([O:15][C:13]([N:20]1[CH2:25][CH2:24][CH:23]([NH:1][C:2]2[CH:12]=[CH:11][C:5]([C:6](=[O:7])[N:8]([CH3:10])[CH3:9])=[CH:4][CH:3]=2)[CH2:22][CH2:21]1)=[O:14])([CH3:19])([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 2355274-Amino-N,N-dimethylbenzamideHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 68968986HCID 68968986, compoundYield 100%

Procedure

Using general procedure A, 4-amino-N,N-dimethyl-benzamide (Schiemenz, G. P.; Stein, G., Tetrahedron, 26, 1970, 2007-2026) (619 mg, 3.77 mmol) and 1-Boc-4-piperidone (901 mg, 4.52 mmol) gave 4-(4-dimethylcarbamoyl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester as a white solid (1.31 g).

Sources & evidence

ORD record
ord-94fec74140a94d16be8673bb37abee51
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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