HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-oxopiperidine-1-carboxylate → 4-(4-Tert-butoxycarbonylmethoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Reactant | Tert-butyl 2-(4-aminophenoxy)acetate | HCID 22060435 | — |
| Product | 4-(4-Tert-butoxycarbonylmethoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester | HCID 68968832 | 95% |
Reaction Steps
Using general procedure A, (4-amino-phenoxy)-acetic acid tert-butyl ester (Renodon-Corniere, Axelle; et al., J. Med. Chem., 45, 4, 2002, 944-954) (4.84 g, 21.6 mmol) and 1-Boc-4-piperidone (3.4 g, 17.1 mmol) afforded 4-(4-tert-butoxycarbonylmethoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester (6.6 g, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491735B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-55a3b5e3b35847d6814d4e7f2c23aa78 |
| Source note | uspto-grants-2009_02 |