tert-Butyl 4-oxopiperidine-1-carboxylate → HCID 68972469, compound

HRID 1726203Notes

Reaction equation

HRID 1726203 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:12])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[C:20]([N:27]1[CH2:32][CH2:31][C:30](=O)[CH2:29][CH2:28]1)([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21]>>[C:23]([O:22][C:20]([N:27]1[CH2:32][CH2:31][CH:30]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([S:8](=[O:10])(=[O:9])[N:11]([CH2:13][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH3:12])=[CH:4][CH:3]=2)[CH2:29][CH2:28]1)=[O:21])([CH3:26])([CH3:24])[CH3:25]

Participants

3

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 8326284-amino-N-benzyl-N-methylbenzenesulfonamide

Product 1

HCID 68972469HCID 68972469, compoundYield 64%

Procedure

Using general procedure A, 4-amino-N-benzyl-N-methyl-benzenesulfonamide (Mikhura, I. V.; et al., Russ. J. Org. Chem., 36, 1, 2000, 64-68) (852 mg, 3.09 mmol) and 1-Boc-4-piperidone (677 mg, 3.40 mmol) afforded 4-[4-(benzyl-methyl-sulfamoyl)-phenylamino]-piperidine-1-carboxylic acid tert-butyl ester as a white solid (796 mg, 64%).

Sources & evidence

ORD record
ord-c36ed4ebfeed4a2fa4d3cd7e363d0987
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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