Benzonitrile, 3-(bromomethyl)- → 4-{(3-Cyano-benzyl)-[4-(4-methoxycarbonyl-phenoxy)-phenyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	Benzonitrile, 3-(bromomethyl)-	HCID 97249	—
Reactant	HCID 68968593	HCID 68968593	—
Product	4-{(3-Cyano-benzyl)-[4-(4-methoxycarbonyl-phenoxy)-phenyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester	HCID 68971712	90%

Reaction Steps

Using general procedure H, 4-[4-(4-methoxycarbonyl-phenoxy)-phenylamino]-piperidine-1-carboxylic acid tert-butyl ester (see EXAMPLE 96) (440 mg, 1.07 mmol) and 3-cyanobenzyl bromide (314 mg, 1.6 mmol) afforded 4-{(3-cyano-benzyl)-[4-(4-methoxycarbonyl-phenoxy)-phenyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester as a white solid (520 mg, 90%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07491735B2
Source dataset	uspto-grants-2009_02
ORD ID	ord-e122e4dc61a54937a85291b3f53e3eb2
Source note	uspto-grants-2009_02