4,6-Dimethylpyrimidine-5-carboxylic acid → HCID 68971776, compound

Participants

Reaction Steps

Using general procedure E with the primary amine (73 mg, 0.17 mmol) and 4,6-dimethylpyrimidine-5-carboxylic acid (37 mg, 0.24 mmol) followed by general procedure K with the resulting ester gave 4-[(3-cyano-benzyl)-(1-{3-[(4,6-dimethyl-pyrimidine-5-carbonyl)-amino]-1-methyl-propyl}-piperidin-4-yl)-amino]-benzoic acid as a beige solid (43.4 mg, 46% over 2 steps).

Provenance & Evidence