2-Chloro-6-methylbenzoic acid → HCID 68973588, compound

Participants

Reaction Steps

Using general procedure E, 4-[[1-(3-amino-1-methyl-propyl)-piperidin-4-yl]-(5-chloro-2-fluoro-benzyl)-amino]-N,N-dibenzyl-benzenesulfonamide (see EXAMPLE 209) (339 mg, 0.52 mmol) and 2-chloro-6-methylbenzoic acid (116 mg, 0.68 mmol) afforded 2-chloro-N-(3-{4-[(5-chloro-2-fluoro-benzyl)-(4-dibenzylsulfamoyl-phenyl)-amino]-piperidin-1-yl}-butyl)-6-methyl-benzamide as a yellow oil (387 mg, 100%).

Provenance & Evidence