2-(Bromomethyl)-4-chloro-1-fluorobenzene → HCID 68968853, compound

Participants

Reaction Steps

Using general procedure H with 4-(benzo[1,3]dioxol-5-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (see EXAMPLE 179) (320 mg, 1.0 mmol) and 2-fluoro-5-chlorobenzyl bromide (291 mg, 1.3 mmol) and then using general procedure C afforded benzo[1,3]dioxol-5-yl-(5-chloro-2-fluoro-benzyl)-piperidin-4-yl-amine as a white solid (323 mg, 89% over 2 steps).

Provenance & Evidence