3-(Bromomethyl)-4-fluorobenzonitrile → 4-{(5-Cyano-2-fluoro-benzyl)-[4-(4-methoxycarbonyl-phenoxy)-phenyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	3-(Bromomethyl)-4-fluorobenzonitrile	HCID 16227236	—
Reactant	HCID 68968593	HCID 68968593	—
Product	4-{(5-Cyano-2-fluoro-benzyl)-[4-(4-methoxycarbonyl-phenoxy)-phenyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester	HCID 68971721	89.3%

Reaction Steps

Using general procedure H, 4-[4-(4-methoxycarbonyl-phenoxy)-phenylamino]-piperidine-1-carboxylic acid tert-butyl ester (see EXAMPLE 96) (430 mg, 1.04 mmol) and 2-fluoro-5-cyanobenzyl bromide (289 mg, 1.35 mmol) afforded 4-{(5-cyano-2-fluoro-benzyl)-[4-(4-methoxycarbonyl-phenoxy)-phenyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester as a white solid (520 mg, 89%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07491735B2
Source dataset	uspto-grants-2009_02
ORD ID	ord-12c7a29e58e9491d99511fd5b5619c68
Source note	uspto-grants-2009_02