1-Boc-4-[Hydroxy-(4-trifluoromethoxyphenyl)methyl]piperidine → tert-Butyl 4-(4-(trifluoromethoxy)benzoyl)piperidine-1-carboxylate

Participants

Reaction Steps

To a solution of 4-[hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (see EXAMPLE 32) (604 mg, 1.61 mmol) in CH2Cl2 (8 mL) was added SiO2 (2 g) followed by PCC (1.04 g, 4.82 mmol), and the mixture was stirred at room temperature for 3 h to give 4-(4-trifluoromethoxy-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester as colourless crystals (601 mg, 100%) after purification.

Provenance & Evidence