HuagongsheHuagongshe Chemistry Print Report · For research reference only
Catechol → HCID 68970773, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Catechol | HCID 289 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | (4-Bromophenyl)(piperidin-4-yl)methanone | HCID 13180300 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 68970773 | HCID 68970773 | 87.3% |
Reaction Steps
A mixture of (4-bromophenyl)-piperidin-4-yl-methanone (536 mg, 2.00 mmol), catechol (880 mg, 8.00 mmol) and p-TsOH.H2O (760 mg, 4.00 mmol) in xylene (20 mL) was heated at reflux with a Dean-Stark apparatus to remove water for 68 hours. Standard work-up and purification gave 4-[2-(4-bromophenyl)-benzo[1,3]dioxol-2-yl]-piperidine (629 mg, 87%) as a yellow foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491735B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-f9627ad9526b48589f96430246319e0c |
| Source note | uspto-grants-2009_02 |