2-(3-Oxobutyl)isoindoline-1,3-dione → HCID 68968770, compound

HRID 1726250Notes

Reaction equation

HRID 1726250 reaction equation
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[O:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[O:10]2)=[CH:5][CH:4]=1.O=[C:25]([CH3:39])[CH2:26][CH2:27][N:28]1C(=O)C2C(=CC=CC=2)C1=O>>[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([CH:18]3[CH2:23][CH2:22][N:21]([CH:25]([CH3:39])[CH2:26][CH2:27][NH2:28])[CH2:20][CH2:19]3)[O:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[O:10]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 2907282-(3-Oxobutyl)isoindoline-1,3-dioneHCID 68968790HCID 68968790, compound

Product 1

HCID 68968770HCID 68968770, compound

Procedure

Using general procedure B with the above amine (65 mg, 0.20 mmol) and 2-(3-oxo-butyl)-isoindole-1,3-dione (86 mg, 0.40 mmol) and then using general procedure D afforded 3-{4-[2-(4-methylsulfanyl-phenyl)-benzo[1,3]dioxol-2-yl]-piperidin-1-yl}-butylamine as a white solid (42 mg, 53% over 2 steps).

Sources & evidence

ORD record
ord-9f5f727a6eb042c0832dd7d32a4c87b2
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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