HuagongsheHuagongshe Chemistry Print Report · For research reference only
Catechol → HCID 68969824, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Catechol | HCID 289 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | tert-Butyl 4-(4-chlorobenzoyl)piperidine-1-carboxylate | HCID 10519988 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 68969824 | HCID 68969824 | 50.3% |
Reaction Steps
The above ketone (450 mg, 1.39 mmol), catechol (614 mg, 5.58 mmol), p-TsOH.H2O (529 mg, 2.78 mmol), toluene (5 mL) and xylene (15 mL) were heated at 185° C. overnight using a Dean-Stark apparatus to remove water. Work-up and purification afforded 4-[2-(4-chloro-phenyl)-benzo[1,3]dioxol-2-yl]-piperidine as a pink oil (221 mg, 50%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491735B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-51449001a4424fef9a9cbce0090b02f1 |
| Source note | uspto-grants-2009_02 |