HuagongsheHuagongshe Chemistry Print Report · For research reference only
Catechol → HCID 68972901, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Catechol | HCID 289 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | tert-Butyl 4-(4-methoxybenzoyl)piperidine-1-carboxylate | HCID 49760136 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 68972901 | HCID 68972901 | 36% |
Reaction Steps
A solution of the above ketone (957 mg, 3.00 mmol), catechol (660 mg, 6.00 mmol) and p-TsOH.H2O (1.14 g, 6.00 mmol) in xylene (20 mL) was heated at reflux using a Dean-Stark apparatus to remove water for 24 hours. Standard work-up and purification gave 4-[2-(4-methoxy-phenyl)-benzo[1,3]dioxol-2-yl]-piperidine as a pale yellow oil (335 mg, 36%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491735B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-d94b9e0bf74742269cc86473f0e2fd20 |
| Source note | uspto-grants-2009_02 |