4-Fluorocatechol → HCID 68968782, compound

Participants

Reaction Steps

A solution of 4-(4-methylsulfanyl-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester (see EXAMPLE 28) (168 mg, 0.50 mmol), 4-fluorocatechol (128 mg, 2.0 mmol) and p-TsOH.H2O (190 mg, 1.0 mmol) in xylene (50 mL) was heated at reflux under a Dean-Stark trap for 41 hours. Standard work-up and purification gave 4-[5-fluoro-2-(4-methylsulfanyl-phenyl)-benzo[1,3]dioxol-2-yl]-piperidine as a white solid (58 mg, 34%).

Provenance & Evidence