HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorocatechol → HCID 68970624, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorocatechol | HCID 160458 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | tert-Butyl 4-(4-methoxybenzoyl)piperidine-1-carboxylate | HCID 49760136 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 68970624 | HCID 68970624 | 33.4% |
Reaction Steps
A solution of 4-(4-methoxy-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester (see EXAMPLE 284) (638 mg, 2.00 mmol), 4-fluorocatechol (512 mg, 4.00 mmol) and p-TsOH.H2O (760 mg, 4.00 mmol) in xylene (20 mL) was heated at reflux using a Dean-Stark apparatus to remove water for 52 hours. Standard work-up and purification gave 4-[5-fluoro-2-(4-methoxy-phenyl)-benzo[1,3]dioxol-2-yl]-piperidine as a pale yellow oil (220 mg, 33%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491735B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-94e480d75cd342819f588666288f3fb1 |
| Source note | uspto-grants-2009_02 |