HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromopyridin-3-amine → Tert-butyl 4-((6-bromopyridin-3-yl)amino)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromopyridin-3-amine | HCID 642811 | — |
| Reactant | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Product | Tert-butyl 4-((6-bromopyridin-3-yl)amino)piperidine-1-carboxylate | HCID 86602140 | 58% |
Reaction Steps
Using general procedure A, 5-amino-2-bromopyridine (Binz; v, Schickh, Chem. Ber., 68, 1935, 315-321) (308 mg, 1.78 mmol) and 1-Boc-4-piperidone (317 mg, 1.59 mmol) gave 4-(6-bromo-pyridin-3-ylamino)-piperidine-1-carboxylic acid tert-butyl ester as a yellow solid (326 mg, 58%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491735B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-bb1d3ce785e44ec4bf9c31dd038b667e |
| Source note | uspto-grants-2009_02 |