Aniline → 1-Boc-4-AP

HRID 1726306Notes

Reaction equation

HRID 1726306 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[NH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:4]([O:3][C:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=[O:2])([CH3:7])([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 6115AnilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 14915021-Boc-4-APYield 93%

Procedure

Using general procedure A, 1-Boc-4-piperidone (2.42 g, 12.1 mmol) and aniline (1.0 mL, 11.0 mmol) gave 4-phenylamino-piperidine-1-carboxylic acid tert-butyl ester as a white solid (2.82 g, 93%).

Sources & evidence

ORD record
ord-100e6212906449509387b4a207b8189c
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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