HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluidine → para-methyl 4-Anilino-1-Boc-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluidine | HCID 7813 | — |
| Reactant | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Product | para-methyl 4-Anilino-1-Boc-piperidine | HCID 22557837 | 96.3% |
Reaction Steps
Using general procedure A, 1-Boc-4-piperidone (665 mg, 3.34 mmol) and p-toluidine (322 mg, 3.01 mmol) gave 4-p-tolylamino-piperidine-1-carboxylic acid tert-butyl ester as an off-white solid (842 mg, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491735B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-7d84a38f8fc947569a9cccec8cfad494 |
| Source note | uspto-grants-2009_02 |