HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (2r)-3-Aza-2-phenyl-4-(3,5-dimethylphenyl)but-3-en-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Benzaldehyde, 3,5-dimethyl- | HCID 34225 | — |
| Reactant | 2-Amino-2-phenylethanol | HCID 92466 | — |
| Product | (2r)-3-Aza-2-phenyl-4-(3,5-dimethylphenyl)but-3-en-1-ol | HCID 68464252 | — |
Reaction Steps
A solution of 3,5-dimethylbenzaldehyde (30.0 g) and (R)-phenylglycinol (30.7 g) in toluene (200 ml) was refluxed for 3 hours with removing water. The reaction solution was concentrated to give the title compound (59.7 g) having the following physical data.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491748B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-e7f2b641c56243259bebfb11b0aea8ae |
| Source note | uspto-grants-2009_02 |