反应详情

温度

80 °C

Acetonitrile (15 ml) was added to 2-benzyl-4-hydroxymethylene-5-oxazolone sodium salt (1.00 g, 4.44 mmol) and O-methylisourea hydrochloride (0.49 g, 4.44 mmol), and the mixture was stirred overnight at 80° C. The mixture was concentrated under reduced pressure, water (5 ml) was added, and the mixture was stirred at room temperature for 1 hour. Then, the precipitate was collected by filtration and vacuum dried to give 2-methoxy-6-oxo-5-phenylacetylamino-1,6-dihydropyrimidine (0.94 g, 3.64 mmol).

1. concentrationThe mixture was concentrated under reduced pressure, water (5 ml)
2. additionwas added
3. stirringthe mixture was stirred at room temperature for 1 hour
4. filtrationThen, the precipitate was collected by filtration and vacuum
5. customdried