反应详情

温度

80 °C

Acetonitrile (20 ml) was added to 2-methyl-4-hydroxymethylene-5-oxazolone sodium salt (1.00 g, 6.71 mmol) and O-methylisourea hydrochloride (0.74 g, 6.71 mmol), and the mixture was stirred at 80° C. for 2 days. The mixture was concentrated, and methanol (5 ml) and water (3 ml) were added. The mixture was stirred at room temperature for 1 hour. Then, the precipitate was collected by filtration and vacuum dried to give 2-methoxy-6-oxo-5-acetylamino-1,6-dihydropyrimidine (0.91 g, 4.97 mmol).

1. concentrationThe mixture was concentrated
2. additionmethanol (5 ml) and water (3 ml) were added
3. stirringThe mixture was stirred at room temperature for 1 hour
4. filtrationThen, the precipitate was collected by filtration and vacuum
5. customdried