HCID 57433448, compound → HCID 86599716, compound

Participants

Reaction Steps

3-(5-Amino-3-fluoro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester. Four cylinders charged with (S)-3-(3-fluoro-5-nitro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester (50 g), 10% Pd(OH)2/C (5.0 g) and MeOH (300 mL) were subjected to hydrogenation under 50 psi H2. The mixture was stirred vigorously overnight. The mixture was filtered through a pad of diatomaceous earth and rinsed with methanol. The alcoholic solutions were combined and concentrated to give the aniline (S)-3-(5-amino-3-fluoro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester as syrup in quantitative yield.

Provenance & Evidence