HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Acetylpiperazine → HCID 69067028, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Acetylpiperazine | HCID 83795 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | tert-butyl N-((2R)-1-oxopropan-2-yl)carbamate | HCID 10910049 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | HCID 69067028 | HCID 69067028 | 85.1% |
Reaction Steps
(R)-(1-methyl-2-oxo-ethyl)-carbamic acid tert-butyl ester (1.85 g, 10.7 mmole) and acetyl piperazine (1.53 g, 12 mmole) were combined in dichloroethane (125 mL). NaBH(OAc)3 (4.53 g. 21 mmole) was added. The resultant reaction solution was stirred at room temperature for 20 h. An equal volume of saturated NaHCO3 was added. The aqueous phase was extracted 3 times with CH2Cl2. The combined organic extracts were washed with saturated NaCl, dried over Na2SO4 and concentrated under vacuum. Purification by silica chromatography (5% methanol in CH2Cl2 provided (R)-[2-(4-acetylpiperazin-1-yl)-1-methyl-ethyl]-carbamic acid tert-butyl ester (Intermediate XXIXa, 2.6 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491821B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-0e57db2e25ab4001b3874c975e3d9e36 |
| Source note | uspto-grants-2009_02 |