反应详情

To 3-oxo-3-(pyridin-4-yl)propanenitrile (3.40 g; Example 7, Step 1) suspended in 230 mL ethanol was added 2.92 mL hydrazine. The mixture refluxed for 3 hours and concentrated to dryness. The residue was purified by chromatography, eluting with a mixture of 10% methanol in dichloromethane to yield 0.80 g (21% yield) product as a light yellow solid. MS showed a M+1 molecular ion of m/z 161.3 by positive APCI.

1. temperatureThe mixture refluxed for 3 hours
2. concentrationconcentrated to dryness
3. customThe residue was purified by chromatography
4. washeluting with a mixture of 10% methanol in dichloromethane