1,1'-Carbonyldiimidazole → HCID 68787238, compound

Participants

Reaction Steps

The macrocyclic product from Step C (110 mg, 0.22 mmol) was dissolved in DCM (2.2 mL), followed by addition of CDI (45 mg, 0.27 mmol) in one portion. The reaction was stirred at rt overnight. After 15 h, the reaction was complete as monitored by TLC (DCM/MeOH 9:1). Isoindoline (0.12 mL, 1.1 mmol) was added to the reaction drop-wise, and the reaction was stirred at 40° C. for overnight. After 22 h, TLC showed reaction complete. The reaction was cooled to rt, diluted with DCM (6 mL) and washed with 1N aq. HCl (2×2 mL), sat. sodium bicarbonate (2 mL), brine (2 mL), dried (Na2SO4), and concentrated down. The crude was purified on silica gel (Biotage 40S, eluent: 2 to 4% MeOH in DCM), giving the desired product as a white powder (131 mg, 90%).

Provenance & Evidence